Biological chemistry: The making of Moco

The Chemistry of Bread Making

The Journal of Biological Chemistry

Recently, two new amino acids have been isolated from hydrolysates of bovine ligamenturn nuchae elastin by Partridge, Elsden, and Thomas (1). Further studies from the same laboratory (2) have shown the compounds to be structural isomers composed of a pyridinium ring with four side chains located at positions 1, 3, 4, and 5 (desmosine), as depicted in Fig. 1, or at positions 1, 2, 3, and 5 (isod...

The Journal of Biological Chemistry

Hormonal control of the initial step in hepatic gluconeogenesis from pyruvate was examined following acute administration of epinephrine, glucagon, or cortisol to adult rats. After hormonal treatment of the animals, the mitochondria were isolated for the study of pyruvate metabolism. When pyruvate and bicarbonate were the only substrates provided, mitochondrial fixation of carbon dioxide and pr...

The Journal of Biological Chemistry

The fact that individual protein subunits must have different regions in contact with neighboring subunits in any oligomeric assembly greater than a diier is considered in relation to the nature of subunit interactions. Binding equations for this model have been derived for various different tetrameric arrangements and compared with the equations given by other models. Methods of distinguishing...

The Journal of Biological Chemistry

The reactions of iodoacetate and bromoacetate with ribonuclease have already provided some information on the relationship between the chemical structure and the catalytic a(*tivity of the enzyme. It is the purpose of this and the following paper to extend this information. In earlier studies, Gundlach, Stein, and Moore (1) showed that although alkylation at lysine, mrthioninc, or histidine res...